Publications

X and Y chromosomes as determinants of aging and disease
Dubal DB, Ambrosio F, Stout MB, Theodorescu D.
Science. 2026 Oct; 394(6819):53-59.

A National Institute on Aging workshop on sex differences in health across the lifespan
Pea J, Addie S, Ambrosio F, …, Dubal DB.
Nat Aging. 2026 Sep; 6(9):1759-1764.

Female Clinical Resilience Despite Pathologic Risk in Alzheimer Disease
Casaletto KB, Dubal DB.
JAMA. 2026 Jul 14; 336(2):106-108.

Longevity Factor Klotho and Resistance to Cognitive Deficits in Individuals with Parkinson's Disease and in an α-Synuclein Mouse Model
Luthra NS, Bonham LW, Moreno AJ, …, Dubal DB.
J Neurosci. 2026 May 6; 46(18).

Age-related alterations in plasma biomarkers of relevance to Alzheimer's disease are attenuated in KLOTHO KL-VS heterozygotes
Driscoll I, Wilson RE, Johnson SC, Asthana S, Gallagher CL, Hermann BP, Sager MA, Carlsson CM, Blennow K, Zetterberg H, Dubal DB, Okonkwo OC.
J Alzheimers Dis. 2026 Apr; 110(3):1175-1182.

Serum Klotho Levels, Brain Structure, and Cognitive Performance
Czaplicki AM, Frahmand Driscoll I, Ma Y, Gaitán JM, Bendlin BB, Johnson SC, Asthana S, Dubal DB, Okonkwo OC.
JAMA Neurol. 2026 Mar 1; 83(3):259-268.

More fit KL-VS heterozygotes have more favorable AD-relevant biomarker profiles
Jarchow M, Driscoll I, Breidenbach BM, …, Dubal DB.
Alzheimers Dement (N Y). 2025 Jul-Sep; 11(3):e70133.

Strategies for studying sex differences in brain aging
Ansere VA, Kim SS, Marino F, Morillo K, Dubal DB, Murphy CT, Suh Y, Benayoun BA.
Trends Genet. 2025 Aug; 41(8):678-690.

Aging activates escape of the silent X chromosome in the female mouse hippocampus
Gadek M, Shaw CK, Abdulai-Saiku S, …, Dubal DB.
Sci Adv. 2025 Mar 7; 11(10):eads8169.

The maternal X chromosome affects cognition and brain ageing in female mice
Abdulai-Saiku S, Gupta S, Wang D, Marino F, Moreno AJ, Huang Y, Srivastava D, Panning B, Dubal DB.
Nature. 2025 Feb; 638(8049):152-159.

Biological sex matters in brain aging
Dubal DB, Murphy CT, Suh Y, Benayoun BA.
Neuron. 2025 Jan 8; 113(1):2-6.

Tlr7 drives sex differences in age- and Alzheimer's disease-related demyelination
Lopez-Lee C, Kodama L, Fan L, …, Dubal DB.
Science. 2024 Nov 29; 386(6725):eadk7844.

Amyloid-β positivity is less prevalent in cognitively unimpaired KLOTHO KL-VS heterozygotes
Cook N, Driscoll I, Gaitán JM, …, Dubal DB.
J Alzheimers Dis. 2024 Nov; 102(2):480-490.

β-Amyloid in Cognitively Unimpaired Individuals-Blame Mom?
Dubal DB, Elser HC.
JAMA Neurol. 2024 Aug 1; 81(8):795-797.

Sex and gender differences in cognitive resilience to aging and Alzheimer's disease
Arenaza-Urquijo EM, Boyle R, Casaletto K, …, Dubal DB.
Alzheimers Dement. 2024 Aug; 20(8):5695-5719.

Plasma phosphorylated tau-217 exhibits sex-specific prognostication of cognitive decline and brain atrophy in cognitively unimpaired adults
Saloner R, VandeVrede L, Asken BM, …, Dubal DB.
Alzheimers Dement. 2024 Jan; 20(1):376-387.

Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice
Park C, Hahn O, Gupta S, Moreno AJ, Marino F, Kedir B, Wang D, Villeda SA, Wyss-Coray T, Dubal DB.
Nat Aging. 2023 Sep; 3(9):1067-1078.

Associations between klotho and telomere biology in high stress caregivers
Brown RL, Epel EE, Lin J, Dubal DB, Prather AA.
Aging (Albany NY). 2023 Aug 14; 15(15):7381-7396.

Longevity factor klotho enhances cognition in aged nonhuman primates
Castner SA, Gupta S, Wang D, …, Dubal DB.
Nat Aging. 2023 Aug; 3(8):931-937.

The mitochondrial unfolded protein response regulates hippocampal neural stem cell aging
Wang CL, Ohkubo R, Mu WC, Chen W, Fan JL, Song Z, Maruichi A, Sudmant PH, Pisco AO, Dubal DB, Ji N, Chen D.
Cell Metab. 2023 Jun 6; 35(6):996-1008.e7.

X Chromosome Factor Kdm6a Enhances Cognition Independent of Its Demethylase Function in the Aging XY Male Brain
Shaw CK, Abdulai-Saiku S, Marino F, Wang D, Davis EJ, Panning B, Dubal DB.
J Gerontol A Biol Sci Med Sci. 2023 Jun 1; 78(6):938-943.

AD-associated CSF biomolecular changes are attenuated in KL-VS heterozygotes
Driscoll I, Ma Y, Lose SR, …, Dubal DB.
Alzheimers Dement (Amst). 2022; 14(1):e12383.

Rare APOE Missense Variants-Can We Overcome APOE ε4 and Alzheimer Disease Risk?
Rabinovici GD, Dubal DB.
JAMA Neurol. 2022 Jul 1; 79(7):649-651.

An Integrated Analysis of Clinical, Genomic, and Imaging Features Reveals Predictors of Neurocognitive Outcomes in a Longitudinal Cohort of Pediatric Cancer Survivors, Enriched with CNS Tumors (Rad ART Pro)
Kline C, Stoller S, Byer L, Samuel D, Lupo JM, Morrison MA, Rauschecker AM, Nedelec P, Faig W, Dubal DB, Fullerton HJ, Mueller S.
Front Oncol. 2022; 12:874317.

KL1 Domain of Longevity Factor Klotho Mimics the Metabolome of Cognitive Stimulation and Enhances Cognition in Young and Aging Mice
Gupta S, Moreno AJ, Wang D, …, Dubal DB.
J Neurosci. 2022 May 11; 42(19):4016-4025.

KIBRA, MTNR1B, and FKBP5 genotypes are associated with decreased odds of incident delirium in elderly post-surgical patients
Terrelonge M, LaHue SC, Tang C, Movsesyan I, Pullinger CR, Dubal DB, Leung J, Douglas VC.
Sci Rep. 2022 Jan 11; 12(1):556.

Sex-Stratified Single-Cell RNA-Seq Analysis Identifies Sex-Specific and Cell Type-Specific Transcriptional Responses in Alzheimer's Disease Across Two Brain Regions
Belonwu SA, Li Y, Bunis D, Rao AA, Solsberg CW, Tang A, Fragiadakis GK, Dubal DB, Oskotsky T, Sirota M.
Mol Neurobiol. 2022 Jan; 59(1):276-293.

Circulating Klotho Is Higher in Cerebrospinal Fluid than Serum and Elevated Among KLOTHO Heterozygotes in a Cohort with Risk for Alzheimer's Disease
Gaitán JM, Asthana S, Carlsson CM, Engelman CD, Johnson SC, Sager MA, Wang D, Dubal DB, Okonkwo OC.
J Alzheimers Dis. 2022; 90(4):1557-1569.

Sex-Specific Association of the X Chromosome With Cognitive Change and Tau Pathology in Aging and Alzheimer Disease
Davis EJ, Solsberg CW, White CC, Miñones-Moyano E, Sirota M, Chibnik L, Bennett DA, De Jager PL, Yokoyama JS, Dubal DB.
JAMA Neurol. 2021 Oct 1; 78(10):1249-1254.

Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer's Disease
Gaitán JM, Moon HY, Stremlau M, Dubal DB, Cook DB, Okonkwo OC, van Praag H.
Front Endocrinol (Lausanne). 2021; 12:660181.

Sugar sweetened beverage consumption is positively associated with Klotho levels at two years of age in LatinX youth
Villagomez S, Dubal DB, Hawkins J, Wang D, Wojcicki JM.
BMC Nutr. 2021 Apr 23; 7(1):22.

Age-Related Tau Burden and Cognitive Deficits Are Attenuated in KLOTHO KL-VS Heterozygotes
Driscoll I, Ma Y, Gallagher CL, …, Dubal DB.
J Alzheimers Dis. 2021; 79(3):1297-1305.

A second X chromosome contributes to resilience in a mouse model of Alzheimer's disease
Davis EJ, Broestl L, Abdulai-Saiku S, …, Dubal DB.
Sci Transl Med. 2020 Aug 26; 12(558).

Sexual dimorphism of physical activity on cognitive aging: Role of immune functioning
Casaletto KB, Lindbergh C, Memel M, …, Dubal DB.
Brain Behav Immun. 2020 Aug; 88:699-710.

Longevity Gene KLOTHO and Alzheimer Disease-A Better Fate for Individuals Who Carry APOE ε4
Dubal DB, Yokoyama JS.
JAMA Neurol. 2020 Jul 1; 77(7):798-800.

Sex difference in Alzheimer's disease: An updated, balanced and emerging perspective on differing vulnerabilities
Dubal DB.
Handb Clin Neurol. 2020; 175:261-273.

Pathways to brain resilience
Dubal DB.
Nat Med. 2019 Jul; 25(7):1027.

KLOTHO heterozygosity attenuates APOE4-related amyloid burden in preclinical AD
Erickson CM, Schultz SA, Oh JM, Darst BF, Ma Y, Norton D, Betthauser T, Gallagher CL, Carlsson CM, Bendlin BB, Asthana S, Hermann BP, Sager MA, Blennow K, Zetterberg H, Engelman CD, Christian BT, Johnson SC, Dubal DB, Okonkwo OC.
Neurology. 2019 Mar 13; doi: 10.1212/WNL.0000000000007323

Female XX sex chromosomes increase survival and extend lifespan in aging mice
Davis EJ, Lobach I, Dubal DB.
Aging Cell. 2018 Dec 17; doi: 10.1111/acel.12871.

Ovarian Cycle Stages Modulate Alzheimer-Related Cognitive and Brain Network Alterations in Female Mice
Broestl L, Worden K, Moreno AJ, Davis EJ, Wang D, Garay B, Singh T, Verret L, Palop JJ, Dubal DB.
eNeuro. 2018 Dec 3; doi: https://doi.org/10.1523/ENEURO.0132-17.2018.

Cord blood klotho levels are inversely associated with leptin in healthy Latino neonates at risk for obesity
Wojcicki JM, Prather AA, Epel E, Wang D, Dubal DB.
Journal of Pediatric Endocrinology and Metabolism. 2018 Apr 12; doi:https://doi.org/10.1515/jpem-2017-0357.

Apolipoprotein E ε4 and Risk Factors for Alzheimer Disease-Let's Talk About Sex.
Dubal DB, Rogine C.
JAMA Neurology. 2017 Aug 28; doi: 10.1001/jamaneurol.2017.1470.

Peripheral Elevation of a Klotho Fragment Enhances Brain Function and Resilience in Young, Aging, and α-Synuclein Transgenic Mice
Leon J, Moreno AJ, Garay BI, Chalkley RJ, Burlingame AL, Wang D, Dubal DB.
Cell Rep. 2017 Aug 8; 20(6):1360-1371.

Longevity factor klotho and chronic psychological stress
Prather AA, Epel ES, Arenander J, Broestl L, Garay BI, Wang D, Dubal DB.
Translational Psychiatry. 2015;5:e585. doi: 10.1038/tp.2015.81. Epub 2015 June 16.

Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice
Dubal DB, Zhu L, Sanchez PE, Worden K, Broestl L, Johnson E, Ho K, Yu GQ, Kim D, Betourne A, Kuro-O M, Masliah E, Abraham CR, Mucke L.
J Neurosci. 2015 Feb 11;35(6):2358-71.

Variation in longevity gene KLOTHO is associated with greater cortical volumes
Yokoyama JS, Sturm VE, Bonham LW, Klein E, Arfanakis K, Yu L, Coppola G, Kramer JH, Bennett DA, Miller BL, Dubal DB
Ann Clin Transl Neurol. 2015 Mar;2(3):215-30. doi: 10.1002/acn3.161. Epub 2015 Jan 26.

Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory
Orr AG, Hsiao EC, Wang MM, Ho K, Kim DH, Wang X, Guo W, Kang J, Yu GQ, Adame A, Devidze N, Dubal DB, Masliah E, Conklin BR, Mucke L
Nat Neurosci. 2015 Mar;18(3):423-34. doi: 10.1038/nn.3930. Epub 2015 Jan 26.